Proton Therapy Publications by SAH Medical Team
More Publications by Topic
| Bones |
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| Proton‐based radiotherapy for unresectable or incompletely resected osteosarcoma I. Frank Ciernik MD, Andrzej Niemierko PhD, David C. Harmon MD, Wendy Kobayashi BA, Yen‐Lin Chen MD, Torunn, I. Yock MD, David H. Ebb MD, Edwin Choy MD, PhD ; Cancer 2011;117:4522–30. |
| Current Therapeutic Strategies and Novel Approaches in Osteosarcoma Kosei Ando, Marie-Françoise Heymann, Verena Stresing, Kanji Mori, Françoise Rédini and Dominique Heymann ; Cancers 2013, 5(2), 591-616 |
| Non-Randomized Therapy Trial to Determine the Safety and Efficacy of Heavy Ion Radiotherapy in Patients with Non-Resectable Osteosarcoma. Blattmann, Claudia, et al. ; BMC Cancer, vol. 10, no. 1, Dec. 2010, doi:10.1186/1471-2407-10-96. |
| Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up P.G CASALI et al. - Ann Oncol (2018) 29 (Suppl 4): iv79–iv95. |
| Brain & CNS | |
|---|---|
| AVMs | Michel Schlienger et al., “Linac Radiosurgery for Cerebral Arteriovenous Malformations: Results in 169 Patients,” International Journal Radiation Oncology Biology Physics 46 (2000): 1135-1142 |
| Lloyd Miyawaki et al., “Five Year Results of Linac Radiosurgery for Arteriovenous Malformations: Outcome for Large AVMs,” International Journal Radiation Oncology Biology Physics 44 (1999): 1089-1106 | |
| Frederik Vernimmen et al., “Stereotactic Proton Beam Therapy for Intracranial Arteriovenous Malformations,” International Journal Radiation Oncology Biology Physics 62 (2005): 44-52 | |
| RN Kjellberg et al., “Bragg-Peak Proton-Beam Therapy for Arteriovenous Malformations of the Brain,” The New England Journal of Meicine 309 (1983): 269-274 | |
| Fred Barker et al., “Dose–Volume Prediction of Radiation-related Complications After Proton Beam Radiosurgery for Cerebral Arteriovenous Malformations,” Journal Neurosurgery 99 (2003): 254-263 | |
| Long-Term Outcomes iThemba Labs | Frederik Vernimmen et al., “15-Years of Proton Radiosurgery Experience at iThemba Labs, Long Term Results for AVMs, Meningiomas and Acoustic Neuromas ,” PTCOG 42 (2008): O2 |
| Meningiomas | Juergen Debus et al., “High Efficacy of Fractionated Stereotactic Radiotherapy of Large Base-of-Skull Meningiomas: Long-Term Results,” Journal of Clinical Oncology 19 (2001): 3547-3553 |
| Georges Noel et al., “Functional Outcomes of Patients with Benign Meningiomas Treated by 3D Conformal Irradiation with a Combination of Photons and Protons,” International Journal Radiation Oncology Biology Physics 62 (2005): 1412-1422 | |
| Frederik Vernimmen et al., “Stereotactic Proton Beam Therapy of Skull Base Meningiomas,” International Journal Radiation Oncology Biology Physics 49 (2001): 99-105 | |
| Evelyn Wenkel et al., “Benign Meningioma: Partially Resected, Biopsied and Recurrent Intracranial Tumors Treated with Combined Proton and Photon Radiotherapy,” International Journal Radiation Oncology Biology Physics 48 (2000): 1363-1370 | |
| Christos Boskos et al., “Combined Proton and Photon Conformal Radiotherapy for Intracranial Atypical and Malignant Meningioma,” International Journal Radiation Oncology Biology Physics 75 (2009): 399-406 | |
| Spine Sarcomas | Thomas DeLaney et al., “Phase II Study of High-Dose Photon/Proton Radiotherapy in the Management of Spine Sarcomas,” International Journal Radiation Oncology Biology Physics 74 (2009): 732-739 |
| Eyes |
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| Jean-Pierre Caujolle et al., “Proton Beam Radiotherapy for Uveal Melanomas at Nice Teaching Hospital: 16 Years’ Experience,” International Journal Radiation Oncology Biology Physics (2009): 1-6 |
| John Munzenrider, “Uveal Melanomas,” Hematology/Oncology Clinics of North America 15 (2001): 389-402 |
| Bekkering, Geertruida E., et al. “The Effectiveness and Safety of Proton Radiation Therapy for Indications of the Eye.” Strahlentherapie Und Onkologie, vol. 185, no. 4, 2009, pp. 211–221., doi:10.1007/s00066-009-1900-4. |
| Char, Devron H., et al. “Laser and Proton Radiation to Reduce Uveal Melanoma–Associated Exudative Retinal Detachments.” American Journal of Ophthalmology, vol. 136, no. 1, 2003, pp. 180–182., doi:10.1016/s0002-9394(02)02292-4. |
| Ciulla, Thomas A, et al. “Proton Therapy for Exudative Age-Related Macular Degeneration: a Randomized, Sham-Controlled Clinical Trial.” American Journal of Ophthalmology, vol. 134, no. 6, 2002, pp. 905–906., doi:10.1016/s0002-9394(02)01821-4. |
| Chang JW, Yu YS, Kim JY, et al. The Clinical Outcomes of Proton Beam Radiation Therapy for Retinoblastomas That Were Resistant to Chemotherapy and Focal Treatment. Korean Journal of Ophthalmology : KJO. 2011;25(6):387-393. doi:10.3341/kjo.2011.25.6.387. |
| Mouw KW, Sethi RV, Yeap BY, et al. Proton Radiotherapy for the Treatment of Retinoblastoma. International journal of radiation oncology, biology, physics. 2014;90(4):863-869. doi:10.1016/j.ijrobp.2014.07.031. |
| Krengli, Marco et al., Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements International Journal of Radiation Oncology • Biology • Physics , Volume 61 , Issue 2 , 583 - 593 |
| Head and Neck | |
|---|---|
| Clinical Outcomes | Jerry Slater et al., “Proton Radiation for Treatment of Cancer of the Oropharynx: Early Experience at Loma Linda University Medical Center Using a Concomitant Boost Technique,” International Journal Radiation Oncology Biology Physics 62 (2005): 494-500 |
| A.W. Chan, “Change in Patterns of Relapse After Combined Proton and Photon Irradiation for Locally Advanced Paranasal Sinus Cancer,” International Journal Radiation Oncology Biology Physics 60 Volume 1 Supplement (2004): S320 | |
| Clinical Reviews | Annie Chan and Norbert Liebsch, “Proton Radiation Therapy for Head and Neck,” Journal of Surgical Oncology 97 (2008): 697-700 |
| Dosimetry Slides | Ulrike Mock et al., “Treatment Planning Comparison of Conventional, 3D Conformal, Intensity Modulated Photon (IMRT) and Proton Therapy for Paranasal Sinus Carcinoma,” International Journal Radiation Oncology Biology Physics 58 (2004): 147-154 |
| M Krengli et al., “Treatment Planning Comparison of Photon IMRT, Active and Passive Proton Therapy, and Carbon Ion Therapy for Treatment of Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics, Proceedings of the 48th Annual ASTRO Meeting (2006): S669 | |
| Marloes Steneker, Antony Lomax and Uwe Schneider, “Intensity Modulated Photon and Proton Therapy for the Treatment of Head and Neck Tumors,” Radiotherapy and Oncology 80 (2006): 263-267 | |
| Dosimetry Slides | D Yeung et al., “Dosimetric Comparison of IMRT and Proton Therapy for Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S412 |
| Seminal Papers | |
| Acceleration Fractionation | Karen Fu et al., “A Radiation Therapy Oncology Group Phase III Randomized Study to Compare Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinomas: First Report of RTOG 9003,” International Journal Radiation Oncology Biology Physics 48 (2000): 7-16 |
| A Trotti et al., “Long Term Outcomes of RTOG 90–03: A Comparison of Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinoma,” International Journal Radiation Oncology Biology Physics 63 Number 2 Supplement (2005): S70 | |
| H Rodney Withers and Lester Peters, “Transmutability of Dose and Time Commentary on the First Report of RTOG 90003 (K. K. Fu et al.),” 48 (2000): 1-2 | |
| Radiation Chemotherapy Treatments | M Al-Sarraf et al., “Chemoradiotherapy versus Radiotherapy in Patients with Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099,” Journal of Clinical Oncology 16 (1998): 1310-1317 |
| Arlene A. Forastiere et al., “Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer,” The New England Journal of Medicine 349 (2003): 2091-2098 | |
| Side Effects | K. S. Clifford Chao et al., “A Prospective Study of Salivary Function Sparing in Patients with Head-and-Neck Cancers Receiving Intensity-Modulated or Three-Dimensional Radiation Therapy: Initial Results,” International Journal Radiation Oncology Biology Physics 49 (2001): 907-916 |
| Avraham Eisbruch et al., “Dose, Volume and Function Relationships in Parotid Salivary Glands Following Conformal and Intensity-Modulated Irradiation of Head and Neck Cancer,” International Journal Radiation Oncology Biology Physics 45 (1999): 577–587 | |
| Avraham Eisbruch et al., “Xerostomia and Its Predictors Following Parotid-Sparing Irradiation of Head-and-Neck Cancer,” International Journal Radiation Oncology Biology Physics 50 (2001): 695-704 | |
| Head and Neck | |
|---|---|
| Clinical Outcomes | Jerry Slater et al., “Proton Radiation for Treatment of Cancer of the Oropharynx: Early Experience at Loma Linda University Medical Center Using a Concomitant Boost Technique,” International Journal Radiation Oncology Biology Physics 62 (2005): 494-500 |
| A.W. Chan, “Change in Patterns of Relapse After Combined Proton and Photon Irradiation for Locally Advanced Paranasal Sinus Cancer,” International Journal Radiation Oncology Biology Physics 60 Volume 1 Supplement (2004): S320 | |
| Clinical Reviews | Annie Chan and Norbert Liebsch, “Proton Radiation Therapy for Head and Neck,” Journal of Surgical Oncology 97 (2008): 697-700 |
| Dosimetry Slides | Ulrike Mock et al., “Treatment Planning Comparison of Conventional, 3D Conformal, Intensity Modulated Photon (IMRT) and Proton Therapy for Paranasal Sinus Carcinoma,” International Journal Radiation Oncology Biology Physics 58 (2004): 147-154 |
| M Krengli et al., “Treatment Planning Comparison of Photon IMRT, Active and Passive Proton Therapy, and Carbon Ion Therapy for Treatment of Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics, Proceedings of the 48th Annual ASTRO Meeting (2006): S669 | |
| Marloes Steneker, Antony Lomax and Uwe Schneider, “Intensity Modulated Photon and Proton Therapy for the Treatment of Head and Neck Tumors,” Radiotherapy and Oncology 80 (2006): 263-267 | |
| Dosimetry Slides | D Yeung et al., “Dosimetric Comparison of IMRT and Proton Therapy for Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S412 |
| Seminal Papers | |
| Acceleration Fractionation | Karen Fu et al., “A Radiation Therapy Oncology Group Phase III Randomized Study to Compare Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinomas: First Report of RTOG 9003,” International Journal Radiation Oncology Biology Physics 48 (2000): 7-16 |
| A Trotti et al., “Long Term Outcomes of RTOG 90–03: A Comparison of Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinoma,” International Journal Radiation Oncology Biology Physics 63 Number 2 Supplement (2005): S70 | |
| H Rodney Withers and Lester Peters, “Transmutability of Dose and Time Commentary on the First Report of RTOG 90003 (K. K. Fu et al.),” 48 (2000): 1-2 | |
| Radiation Chemotherapy Treatments | M Al-Sarraf et al., “Chemoradiotherapy versus Radiotherapy in Patients with Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099,” Journal of Clinical Oncology 16 (1998): 1310-1317 |
| Arlene A. Forastiere et al., “Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer,” The New England Journal of Medicine 349 (2003): 2091-2098 | |
| Side Effects | K. S. Clifford Chao et al., “A Prospective Study of Salivary Function Sparing in Patients with Head-and-Neck Cancers Receiving Intensity-Modulated or Three-Dimensional Radiation Therapy: Initial Results,” International Journal Radiation Oncology Biology Physics 49 (2001): 907-916 |
| Avraham Eisbruch et al., “Dose, Volume and Function Relationships in Parotid Salivary Glands Following Conformal and Intensity-Modulated Irradiation of Head and Neck Cancer,” International Journal Radiation Oncology Biology Physics 45 (1999): 577–587 | |
| Avraham Eisbruch et al., “Xerostomia and Its Predictors Following Parotid-Sparing Irradiation of Head-and-Neck Cancer,” International Journal Radiation Oncology Biology Physics 50 (2001): 695-704 | |
| Lung | |
|---|---|
| Clinical Studies | David Bush et al., “Proton-Beam Radiotherapy for Early-Stage Lung Cancer,” Chest 116 (1999): 1313-1319 |
| David Bush et al., “Hypofractionated Proton Beam Radiotherapy for Stage I Lung Cancer,” Chest 126 (2004): 1198-1203 | |
| Keiji Nihei et al., “High-Dose Proton Beam Therapy for Stage I Non-Small-Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 65 (2006): 107–111 | |
| Reiner Bonnet et al., “Effects of Proton and Combined Proton/Photon Beam Radiation on Pulmonary Function in Patients with Resectable but Medically Inoperable Non-Small Cell Lung Cancer,” Chest 120 (2001): 1803-1810 | |
| Masaharu Hata et al., “Hypofractionated High-Dose Proton Beam Therapy for Stage I Non-Small-Cell Lung Cancer: Preliminary Results of a Phase I/II Clinical Study,” International Journal Radiation Oncology Biology Physics 68 (2007): 786-793 | |
| Foote, Robert L, et al. “The clinical case for proton beam therapy”, Radiation Oncology (London, England), BioMed Central, 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3549771/. | |
| Side Effects | Samir Sejpal et al., “Does Proton Beam Radiotherapy Reduce Treatment Related Pneumonitis Compared to IMRT in Patients with Locally Advanced Non-Small-Cell Lung Cancer Treated with Concurrent Chemotherapy?” PTCOG 47 (2008): O17 |
| Ritsuko Komaki et al., “Reduction of Bone Marrow Suppression for Patients with Stage III NSCLC Treated by Proton and Chemotherapy Compared with IMRT and Chemotherapy” PTCOG 47 (2008): O10 | |
| Mary Graham et al., “Clinical Dose-Volume Histogram Analysis for Pneumonitis after 3D Treatment for Non-Small Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 45 (1999): 323–329 | |
| Aaron Allen et al., “Fatal Pneumonitis Associated with Intensity-Modulated Radiation Therapy for Mesothelioma,” International Journal Radiation Oncology Biology Physics 64 (2006): 640–645 | |
| Ellen Yorke et al., “Correlation of Dosimetric Factors and Radiation Pneumonitis for Non-Small-Cell Lung Cancer Patients in a Recently Completed Dose Escalation Study,” International Journal Radiation Oncology Biology Physics 63 (2005): 672–682 | |
| Yvette Seppenwoolde et al., “Comparing Different NTCP Models that Predict the Incidence of Radiation Pneumonitis,” ,” International Journal Radiation Oncology Biology Physics 55 (2003): 724-735 | |
| Chang, Joe Y. “Proton Beam Radiotherapy and Chemotherapy for Non–Small Cell Lung Cancer.” JAMA Internal Medicine, American Medical Association, 10 Aug. 2017, jamanetwork.com/journals/jamaoncology/article-abstract/2644653?redirect=true. | |
| Treatment Planning Studies | Joe Chang et al., “Significant Reduction of Normal Tissue Dose by Proton Radiotherapy Compared with Three-Dimensional Conformal or Intensity-Modulated Radiation Therapy in Stage I or Stage III Non-Small-Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 65 (2006): 1087-1096 |
| Xiaodong Zhang et al., “Intensity-Modulated Proton Therapy Reduces the Dose to Normal Tissue Compared with Intensity-Modulated Radiation Therapy or Passive Scanning Proton Therapy and Enables Individualized Radical Radiotherapy for Extensive Stage IIIB Non-Small-Cell Lung Cancer: A Virtual Clinical Study,” International Journal Radiation Oncology Biology Physics (2009): 1-10 | |
| Secondary Malignancies | |
|---|---|
| C.S. Chung et al., “Comparative Analysis of Second Malignancy Risk in Patients Treated with Proton Therapy versus Conventional Photon Therapy,” International Journal Radiation Oncology Biology Physics 72 Number 1 Supplement (2008): S8 | |
| S.L. Liauw et al.,” Second Malignancies After Prostate Brachytherapy: Incidence of Bladder and Colorectal Cancers in Patients With 15 Years of Potential Follow-up,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S390 | |
| L.A. McGee et al.,” Comparison of Second Cancer Risk in Prostate Cancer Patients Treated With Neutron/Photon Irradiation, Photon Irradiation, or Prostatectomy,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S318 | |
| Eric Hall, “Intensity-Modulated Radiation Therapy, Protons and the Risk of Second Cancers,” International Journal Radiation Oncology Biology Physics 65 (2006): 1-7 | |
| Bernard Gottschalk, “Neutron Dose in Scattered and Scanned Proton Beams: In Regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1–7),” International Journal Radiation Oncology Biology Physics 66 (2006): 1594 | |
| Wayne Newhauser et al.,” The Risk of Developing a Second Cancer After Receiving Craniospinal Proton Irradiation,” Physics in Medicine and Biology 54 (2009): 2277-2291 | |
| Jonas Fontenot, “Risk of Secondary Malignant Neoplasms from Proton Therapy and Intensity-Modulated X-Ray Therapy for Early-Stage Prostate Cancer,” International Journal Radiation Oncology Biology Physics 74 (2009): 616-622 |
| Pediatrics | |
|---|---|
| Clinical Outcomes | Torunn Yock et al., “Proton Radiotherapy for Orbital Rhabdomyosarcoma: Clinical Outcome and a Dosimetric Comparison with Photons,” International Journal Radiation Oncology Biology Physics 63 (2005): 1161–1168 |
| T.I. Yock et al., “Proton Radiotherapy for Ependymoma: Initial Clinical Outcomes and Dose Comparisons for Intensity Modulated Radiation With Photons, Proton Radiation, and Intensity Modulated Proton Therapy,” International Journal Radiation Oncology Biology Physics, Proceedings of the 49th Annual ASTRO Meeting (2007): S575 | |
| Eugen Hug et al., “Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas,” Strahlentherapie und Onkologie 178 (2002):10–17 | |
| Grace E. Yuh et al., “Reducing Toxicity from Craniospinal Irradiation: Using Proton Beams to Treat Medulloblastoma in Young Children,” The Cancer Journal 10 (2004): 386-390 | |
| Quoc T. Luu et al., “Fractionated Proton Radiation Treatment for Pediatric Craniopharyngioma: Preliminary Report,” The Cancer Journal 12 (2006): 155-159 | |
| Jean-Louis Habrand, “Proton Therapy in Pediatric Skull Base and Cervical Canal Low-Grade Bone Malignancies,” International Journal Radiation Oncology Biology Physics 71 (2008): 672-675 | |
| Shannon MacDonald et al., “Proton Radiotherapy for Childhood Ependymoma: Initial Clinical Outcomes and Dose Comparisons,” International Journal Radiation Oncology Biology Physics 71 (2008): 979–986 | |
| Hans Peter Rutz et al., “Postoperative Spot-Scanning Proton Radiation Therapy for Chordoma and Chondrosarcoma in Children and Adolescents: Initial Experience at Paul Scherrer Institute,” International Journal Radiation Oncology Biology Physics 71 (2008): 220-225 | |
| S. MacDonald et al., “Proton Radiotherapy for Pediatric Central Nervous System Germ Cell Tumors: Early Clinical Outcomes,” International Journal Radiation Oncology Biology Physics, Proceedings of the 51st Annual ASTRO Meeting (2009): S509 | |
| Armstrong, F. Daniel. “Proton-Beam Radiation Therapy and Health-Related Quality of Life in Children With CNS Tumors.” Journal of Clinical Oncology, vol. 30, no. 17, Oct. 2012, pp. 2028–2029., doi:10.1200/jco.2012.42.1248. | |
| Cotter, Shane E., et al. “Proton Radiotherapy for Solid Tumors of Childhood.” Technology in Cancer Research & Treatment, vol. 11, no. 3, 2012, pp. 267–278., doi:10.7785/tcrt.2012.500295. | |
| Habrand, Jean-Louis, et al. “Proton Therapy in Pediatric Skull Base and Cervical Canal Low-Grade Bone Malignancies.” International Journal of Radiation https://doi.org/10.1016/j.ijrobp.2008.02.043 | |
| Buehrer, S., et al. “Evaluation of Propofol for Repeated Prolonged Deep Sedation in Children Undergoing Proton Radiation Therapy.” British Journal of Anaesthesia, vol. 99, no. 4, 2007, pp. 556–560., doi:10.1093/bja/aem207. | |
| Radiographic Evidence of the Distal Edge | Stephanie Krejcarek et al., “Physiologic and Radiographic Evidence of the Distal Edge of the Proton Beam in Craniospinal Irradiation,” International Journal Radiation Oncology Biology Physics 68 (2007): 646-649 |
| Secondary Malignancies | Raymond Miralbell, Anthony Lomax, Laura Cella and Uwe Schneider, “Potential Reduction of the Incidence of Radiation-Induced Second Cancers by Using Proton Beams in the Treatment of Pediatric Tumors,” International Journal Radiation Oncology Biology Physics 54 (2002): 824-829 |
| Seminal Papers in Pediatric Cancer Treatment | Ching-Hon Pui et al., “Extended Follow-up of Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia,” The New England Journal of Medicine 349 (2003):640-649 |
| Side Effects – Cost Effectiveness | Jonas Lundkvist et al., “Cost-Effectiveness of Proton Radiation in the Treatment of Childhood Medulloblastoma,” Cancer 103 (2005): 793-801 |
| Side Effects – Effects on IQ | Thomas Merchant et al., “Proton Versus Photon Radiotherapy for Common Pediatric Brain Tumors: Comparison of Models of Dose Characteristics and Their Relationship to Cognitive Function,” Pediatric Blood Cancer 51 (2008): 110–117 |
| Thomas Merchant et al., “Modeling Radiation Dosimetry to Predict Cognitive Outcomes in Pediatric Patients with CNS Embryonal Tumors Including Medulloblastoma,” International Journal Radiation Oncology Biology Physics 65 (2006): 210–221 | |
| Thomas Merchant et al., “Radiation Dosimetry Predicts IQ After Conformal Radiation Therapy in Pediatric Patients with Localized Ependymoma,” International Journal Radiation Oncology Biology Physics 63 (2005): 1546-1554 | |
| M Douglas Ris et al., “Intellectual Outcome After Reduced-Dose Radiation Therapy Plus Adjuvant Chemotherapy for Medulloblastoma: A Children’s Cancer Group Study,” Journal of Clinical Oncology 19 (2001): 3470-3476 | |
| Side Effects – Growth Hormone | Thomas Merchant et al., “Radiation Dose-Volume Effects on Growth Hormone Secretion,” International Journal Radiation Oncology Biology Physics 52 (2002): 1264-1270 |
| James Gurney et al., “Endocrine and Cardiovascular Late Effects Among Adult Survivors of Childhood Brain Tumors,” Cancer 97 (2003): 663-673 | |
| Side Effects – Ototoxicity (hearing) | Y Chen et al., “Improved Hearing Outcomes From Cochlear Dose Reduction Using Proton Posterior Fossa Boost in Pediatric Medulloblastoma,” International Journal Radiation Oncology Biology Physics, Proceedings of the 49th Annual ASTRO Meeting (2007): S579 |
| Eugene Huang et al., “Intensity-Modulated Radiation Therapy for Pediatric Medulloblastoma: Early Report on the Reduction of Ototoxicity,” International Journal Radiation Oncology Biology Physics 52 (2002): 599-605 | |
| Side Effects – Secondary Malignancies | Raymond Miralbell et al., “Potential Reduction of the Incidence of Radiation-Induced Second Cancers by Using Proton Beams in the Treatment of Pediatric Tumors,” International Journal Radiation Oncology Biology Physics 54 (2002): 824-829 |
| Side Effects – Thyroid Dysfunction | Umberto Ricardi et al., “Thyroid Dysfunction as a Late Effect in Childhood Medulloblastoma: A comparison of Hyperfractionated versus Conventionally Fractionated Craniospinal Radiotherapy,” International Journal Radiation Oncology Biology Physics 50 (2001): 1287-1294 |
| Treatment Planning | W.H. Clair et al., “Advantage of Protons Compared to Conventional X-ray or IMRT in the Treatment of a Pediatric Patient with Medulloblastoma,” International Journal Radiation Oncology Biology Physics 58 (2004): 727-734 |
| Catherine Lee et al., “Treatment Planning with Protons for Pediatric Retinoblastoma, Medulloblastoma, and Pelvic Sarcoma: How Do Protons Compare with Other Conformal Techniques?” International Journal Radiation Oncology Biology Physics 63 (2005): 362-372 | |
| Marco Krengli et al., “Proton Radiation Therapy for Retinoblastoma: Comparison of Various Intraocular Tumor Locations and Beam Arrangements,” International Journal Radiation Oncology Biology Physics 61 (2005): 583-593 | |
| Prostate | |
|---|---|
| Dose Escalation Trials | Deborah Kuban et al., “Long-Term Results of the M.D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer,” International Journal Radiation Oncology Biology Physics 70 (2008): 67-74 |
| Stephanie Peeters et al., “Dose-Response in Radiotherapy for Localized Prostate Cancer: Results of the Dutch Multicenter Randomized Phase III Trial Comparing 68 Gy of Radiotherapy With 78 Gy,” Journal of Clinical Oncology 24 (2008): 1990-1996 | |
| David P Dearnaley et al., “Escalated-Dose versus Standard-Dose Conformal Radiotherapy in Prostate Cancer: First Results from the MRC RT01 Randomised Controlled Trial,” Lancet Oncology 8 (2007): 475-487 | |
| Anthony Zietman et al., “CORRECTION: Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial,” Journal of American Medicine Association 299 (2008): 899-900 | |
| Anthony Zietman et al., “Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial,” Journal of American Medicine Association 294 (2005): 1233-1239 | |
| A.L. Zietman et al., “A Phase III Trial Employing Conformal Photons with Proton Boost in Early-Stage Prostate Cancer: Conventional Dose (70.2 GyE) Compared to High-Dose Irradiation (79.2 GyE): Long-Term Updated Analysis of Proton Radiation Oncology Group (PROG)/American College of Radiology (ACR) 95–09,” International Journal Radiation Oncology Biology Physics, Proceedings of the 51st Annual ASTRO Meeting (2009): S11 | |
| Gustavo Arruda Viani, “Higher-Than-Conventional Doses in Localized Prostate Cancer Treatment: A Meta-Analysis of Randomized, Controlled Trials,” International Journal Radiation Oncology Biology Physics 74 (2009): 1405–1418 | |
| Loma Linda Experience | Jerry Slater et al., “Proton Therapy for Prostate Cancer: the Initial Loma Linda University Experience,” International Journal Radiation Oncology Biology Physics 59 (2004): 348-352 |
| Jerry Slater et al., “Conformal Proton Therapy for Prostate Carcinoma,” International Journal Radiation Oncology Biology Physics 42 (1998): 299–304 | |
| Quality of Life | J.A. Talcott et al., “Long-Term Quality of Life After Conventional-Dose versus High-Dose Radiation for Prostate Cancer: Results from a Randomized Trial (PROG 95–09),” Journal of Clinical Oncology, 2008 ASCO Annual Meeting Proceedings (Post-Meeting Edition) 26 (2008): 15S |
| Hoppe, Bradford S., et al. “Erectile Function, Incontinence, and Other Quality of Life Outcomes Following Proton Therapy for Prostate Cancer in Men 60 Years Old and Younger.” Cancer, vol. 118, no. 18, 2012, pp. 4619–4626., doi:10.1002/cncr.27398. | |
| Talcott, James A. “Patient-Reported Long-Term Outcomes After Conventional and High-Dose Combined Proton and Photon Radiation for Early Prostate Cancer.” Jama, vol. 303, no. 11, 2010, p. 1046., doi:10.1001/jama.2010.287. | |
| Toxicity | Carlos Vargas et al., “Dose-Volume Comparison of Proton Therapy and Intensity-Modulated Radiotherapy for Prostate Cancer,” International Journal Radiation Oncology Biology Physics 70 (2008): 744–751 |
| Mark Storey et al., “Complications from Radiotherapy Dose Escalation in Prostate Cancer: Preliminary Results of a Randomized Trail,” International Journal Radiation Oncology Biology Physics 48 (2000): 635–642 | |
| Susan Tucker et al., “Comparison of Rectal Dose-Wall Histogram versus Dose-Volume Histogram for Modeling the Incidence of Late Rectal Bleeding after Radiotherapy,” International Journal Radiation Oncology Biology Physics 60 (2004): 1589–1601 | |
| Mendenhall, Nancy P., et al. “Early Outcomes From Three Prospective Trials of Image-Guided Proton Therapy for Prostate Cancer.” International Journal of Radiation Oncology*Biology*Physics, vol. 82, no. 1, 2012, pp. 213–221., doi:10.1016/j.ijrobp.2010.09.024. | |
| Nihei, Keiji, et al. “Multi-Institutional Phase II Study of Proton Beam Therapy for Organ-Confined Prostate Cancer Focusing on the Incidence of Late Rectal Toxicities.” International Journal of Radiation Oncology*Biology*Physics, vol. 81, no. 2, 2011, pp. 390–396., doi:10.1016/j.ijrobp.2010.05.027. | |
| Curtiland Deville Jr, Akansha Jain, Wei-Ting Hwang, Kristina D. Woodhouse, Stefan Both, Shiyu Wang, Peter E. Gabriel, John P. Christodouleas, Justin Bekelman, Zelig Tochner & Neha Vapiwala (2018) Initial report of the genitourinary and gastrointestinal toxicity of post-prostatectomy proton therapy for prostate cancer patients undergoing adjuvant or salvage radiotherapy, Acta Oncologica, DOI: 10.1080/0284186X.2018.1487583 | |
| Treatment Planning | Laura Cella, Anthony Lomax and Raymond Miralbell, “Potential Role of Intensity Modulated Proton Beams in Prostate Cancer Radiotherapy,” International Journal Radiation Oncology Biology Physics 49 (2001): 217–223 |
| Bhishamjit Chera et al., “Dosimetric Study of Pelvic Proton Radiotherapy for High-Risk Prostate Cancer,” International Journal Radiation Oncology Biology Physics 75 (2009): 994–1002 | |
| Hoppe, B.s., et al. “Comparative Effectiveness Study of Proton Therapy Versus IMRT for Definitive Treatment of Prostate Cancer Based on Patient-Reported Outcomes.” International Journal of Radiation Oncology*Biology*Physics, vol. 87, no. 2, 2013, doi:10.1016/j.ijrobp.2013.06.909. | |
